氢氧化镁
Magnesium hydroxide is, after aluminium hydroxide, the most widely used antacid active. 该混合物用于悬浮液和粉末制剂，通常与氢氧化铝结合使用。It has a high acid-binding capacity and reacts rapidly to neutralize gastric acid. The ingestion of pure magnesium hydroxide antacids leads to undesirably high pH values in the stomach, which can, in turn, stimulate acid production. 因此，建议在抗酸制剂中将氢氧化镁与氢氧化铝结合使用。Combination products also overcome the laxative effect of magnesium hydroxide as this is compensated for by the mild obstipative effect of aluminium hydroxide.
Magnesium Hydroxide Powders
GILUMAG® D 211 / D 212 / D 214
Magnesium hydroxide powders are used in the production of tablets, granules and powder mixtures, often in combination with ALUGEL® A 211 or ALUGEL® A 215. They differ with respect to particle size and bulk density.
| 类型 | D 211 | D 212 | D 214 |
| Mg(OH)2 -Assay | 95,0 – 100,5 % | 95,0 – 100,5 % | 95,0 – 100,5 % |
| Density (tapped) | 0,40 – 0,60 g/ml | 0,60 – 0,80 g/ml | 1,01 – 1,25 g/ml |
| d90 | 6 – 10 µm | 10 – 25 µm | 20 – 45 µm |
| Pharmacopoeia | USP, PhEur | USP, PhEur | USP, PhEur |
GILUMAG® D 220
GILUMAG® D 220 is an ultra-fine, low bulk density powder, with a particle size of less than 8 µm. GILUMAG® D 220 具有精细的粒径,可以轻松地混合到这些类型产品的凝胶基体中，适用于软性片剂和糖果配方。
GILUMAG® D 220 is readily mixed with water. The resulting suspensions, after homogenization, are stable, highly viscous, and have a smooth, non-gritty mouth feel. 这些特性使得 GILUMAG® D 220 特别适合与 ALUGEL ® 浆液结合使用，以配制抗酸悬浮液。
| Assay | 95,0 – 100,5 % |
| Density (tapped) | max. 0,41 g/ml |
| d50 | 4 – 8 µm |
| Pharmacopoeia | USP, PhEur |
Magnesium Hydroxide Suspensions
GILUMAG® D 611
GILUMAG® D 611 is a pumpable paste containing approx. 30% Mg(OH)2. It is ideally suited for the production of single and double strength, free-flowing suspensions. Even after long periods of storage D 611 is readily stirred to a homogeneous suspension.
| Assay | 29,0 – 33,0 % Mg(OH)2 |
| Viscosity (Brookfield) | min. 4000 mPa s (LV 3/12) |
| Pharmacopoeia | USP |
GILUMAG® D 661
GILUMAG® D 661 is a highly viscous, thixotropic, paste containing approx. 30 % Mg(OH)2. The high viscosity guarantees excellent storage stability. Single strength or Milk of Magnesia type products can be formulated without the need for additional thickening agents.
| Assay | 29,0 – 33,0 % Mg(OH)2 |
| Viscosity (Brookfield) | min. 1000 mPa s (at 25 %, LV 3/12) |
| Pharmacopoeia | USP |
