晶格层状混合物
Magaldrate
Al5Mg10(OH)31(SO4)2· x H2O
Magaldrate is a lattice layered, crystalline complex of magnesium aluminium hydroxysulphate. It has an exceptionally rapid reaction rate with gastric acid whilst maintaining the stomach pH in the optimum range of 3 - 5. The reaction rate is unaffected by the presence of proteins and pepsin. Magaldrate can adsorb large quantities of bile acids, preventing these aggressors from attacking the mucous membranes.
Magaldrate Powder C 410 / C 411
C410 / C411 are spray dried powders consisting of agglomerations of very fine primary crystals. These agglomerations are mainly spherical in nature, ensuring excellent flow characteristics.
These powder grades are found in the majority of magaldrate tablets in the market today.
| 类型 | C410 | C411 |
| Assay Al(OH)3 (200°C/4h) | 32,1 - 45,9 [%] | 32,1 - 45,9 [%] |
| Assay Mg(OH)2 (200°C/4h) | 49,2 - 66,6 [%] | 49,2 - 66,6 [%] |
| Density (tapped) | 0,4 - 0,6 [g/ml] | 0,6 - 0,8 [g/ml] |
| d50 | 15 - 30 µm | 20 - 35 µm |
| Pharmacopoeia | PhEur, USP | PhEur, USP |
Magaldrate Powder C 425
C425 是一种磨碎的氢氧化铝镁粉末，适用于软性片剂和糖果配方，以及再悬浮的粉末混合物（例如粉末包）。
根据加工条件和配方要求，液体制剂也可以重悬 C425。
| 类型 | C425 |
| Assay Al(OH)3 (200°C/4h) | 32,1 - 45,9 [%] |
| Assay Mg(OH)2 (200°C/4h) | 49,2 - 66,6 [%] |
| Density (tapped) | 0,4 - 0,6 [g/ml] |
| d50 | 5 - 10 µm |
| Pharmacopoeia | PhEur, USP |
Magaldrate Suspension C 632
C 632 is a viscous paste with a magaldrate content of 20 – 25 %. The viscosity borders on the limit of flow capability. The paste is stable on storage and after transportation, displaying only slight sedimentation and no caking. C 632 适用于生产单强度和双强度产品。
Other concentrations of C632 are available on demand.
| 类型 | C632 |
| Assay Al(OH)3 (200°C/4h) | 32,1 - 45,9 [%] |
| Assay Mg(OH)2 (200°C/4h) | 49,2 - 66,6 [%] |
| Viscosity (Brookfield) | max. 400 mPa s (LV 3/12) |
| d50 | 6 - 10 µm |
| Pharmacopoeia | USP |
Hydrotalcite
Al2Mg6(OH)16CO3 · x H2O
Hydrotalcite is a lattice layered, crystalline complex of magnesium aluminium hydroxycarbonate. It contains a higher proportion of magnesium than magaldrate. Hydrotalcite reacts rapidly with gastric acid even in the presence of pepsin and proteins.
Hydrotalcite Powder C 300
C 300 是一种用于所有片剂配方的喷雾干燥粉末，首选在预制粒后使用。
研磨质量可根据要求提供，适用于软性片剂和糖果的配方，或用于液体制剂的重悬。
| 类型 | C300 |
| Assay Al2O3 | 15,3 - 18,7 [%] |
| Assay MgO | 36,0 - 44,0 [%] |
| Density (tapped) | 0,4 - 0,6 [g/ml] |
| d50 | 10 - 30 µm |
| Pharmacopoeia | BP |
Almagate
Al2Mg6(OH)14(CO3)2 · x H2O
Almagate is a crystalline compound similar to hydrotalcite. It reacts very rapidly with gastric acid even in the presence of pepsin and proteins.
Almagate Powder C 310
C310 is a spray dried powder with similar properties to hydrotalcite powder. It is suitable for the production of fast acting tablets.
Almagate Suspension C 610
C610 has an almagate content of ca. 16%. 适用于液体抗酸制剂。
